PDF Search: cardiovascular regeneration and stem cell therapy

Cardiovascular Regeneration And Stem Cell Therapy

Cardiovascular Regeneration and Stem Cell Therapy PDF
Author: Annarosa Leri
Publisher: John Wiley & Sons
Release Date: 2008-04-15
Book Size: 11.14 MB
Book Format: PDF, Docs
Category : Medical
Languages : en
Pages : 248
View: 7171

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Cardiovascular Regeneration And Stem Cell Therapy

by Annarosa Leri, Cardiovascular Regeneration And Stem Cell Therapy Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Cardiovascular Regeneration And Stem Cell Therapy book, This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.



Cardiac Regeneration Using Stem Cells

Cardiac Regeneration using Stem Cells PDF
Author: Keiichi Fukuda
Publisher: CRC Press
Release Date: 2013-04-10
Book Size: 28.74 MB
Book Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 342
View: 1247

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Cardiac Regeneration Using Stem Cells

by Keiichi Fukuda, Cardiac Regeneration Using Stem Cells Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Cardiac Regeneration Using Stem Cells book, To achieve cardiac regeneration using pluripotent stem (iPS) cells, researchers must understand iPS cell generation methods, cardiomyocyte differentiation protocols, cardiomyocyte characterization methods, and tissue engineering. This book presents the current status and future possibilities in cardiac regeneration using iPS cells. Written by top researchers who present new data in these fields, this book reviews cardiac cell therapy for ischemic heart disease and explores in vitro generation of efficacious platelets from iPS cells. It also discusses modeling arrhythmogenic heart disease with patient-specific induced pluripotent stem cells.



Cardiac Regeneration And Repair

Cardiac Regeneration and Repair PDF
Author: Ren-Ke Li
Publisher: Woodhead Publishing
Release Date: 2014-01-22
Book Size: 77.42 MB
Book Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 440
View: 3723

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Cardiac Regeneration And Repair

by Ren-Ke Li, Cardiac Regeneration And Repair Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Cardiac Regeneration And Repair book, Heart disease is the leading cause of death in the UK and the United States. For those who survive heart disease, few victims recover completely. Cell therapies, tissue engineering, and biomaterials technologies have advanced and now offer the potential to reverse the damage caused by heart disease. Volume 1 of this important set provides comprehensive information on the pathology of heart disease and the cell therapies available. Opening chapters look at cardiac pathology and current therapies. Further chapters present gene and protein therapies for regeneration, cell therapies for cardiac regeneration, and clinical considerations of stem cell therapies.



Regenerating The Heart

Regenerating the Heart PDF
Author: Ira S. Cohen
Publisher: Springer Science & Business Media
Release Date: 2011-03-23
Book Size: 74.53 MB
Book Format: PDF
Category : Science
Languages : en
Pages : 558
View: 7583

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Regenerating The Heart

by Ira S. Cohen, Regenerating The Heart Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Regenerating The Heart book, Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield. Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium. This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational examples.



Regenerating The Heart

Regenerating the Heart PDF
Author: Ira S. Cohen
Publisher: Humana Press
Release Date: 2011-04-06
Book Size: 39.87 MB
Book Format: PDF, Mobi
Category : Science
Languages : en
Pages : 558
View: 210

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Regenerating The Heart

by Ira S. Cohen, Regenerating The Heart Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Regenerating The Heart book, Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield. Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium. This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational examples.



Stem Cells And Cardiac Regeneration

Stem Cells and Cardiac Regeneration PDF
Author: Rosalinda Madonna
Publisher: Springer
Release Date: 2015-12-18
Book Size: 65.89 MB
Book Format: PDF, Docs
Category : Science
Languages : en
Pages : 205
View: 1265

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Stem Cells And Cardiac Regeneration

by Rosalinda Madonna, Stem Cells And Cardiac Regeneration Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Stem Cells And Cardiac Regeneration book, This book provides an update of recent advances in the basic and clinical applications of cell-based therapies for myocardial repair and regeneration in ischemic heart disease (IHD) and heart failure (HF). The first sections of the book illuminate basic aspects of stem cells such as definitions, isolation criteria and characterization of embryonic and adult stem cells, as well as pluripotent stem cells and tissue specific progenitor and stem cells. In the following section, the text examines the role of critical regulators of stem cell differentiation in myocardial regeneration, that include circadian rhythyms, microRNAs, epigenetics, microvescicles, and exosomes. The text concludes with a review of the use of stem/progenitor cells in cardiac regeneration and discuss current controversies, unresolved issues, challenges, and future directions. Stem Cells and Cardiac Regeneration is addressed to a wide audience consisting of cardiologists, clinicians, and research scientists, who will learn new concepts in cardiovascular regeneration and repair with special focus on molecular mechanisms and therapeutic potential for cardiovascular regeneration.



Cardiac Regeneration And Repair

Cardiac regeneration and repair PDF
Author: Ren-Ke Li
Publisher: Elsevier
Release Date: 2014-02-16
Book Size: 79.82 MB
Book Format: PDF, Docs
Category : Technology & Engineering
Languages : en
Pages : 440
View: 1542

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Cardiac Regeneration And Repair

by Ren-Ke Li, Cardiac Regeneration And Repair Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Cardiac Regeneration And Repair book, Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function Highlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration



Adult And Pluripotent Stem Cells

Adult and Pluripotent Stem Cells PDF
Author: Jürgen Hescheler
Publisher: Springer Science & Business
Release Date: 2014-04-21
Book Size: 54.73 MB
Book Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 170
View: 381

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Adult And Pluripotent Stem Cells

by Jürgen Hescheler, Adult And Pluripotent Stem Cells Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Adult And Pluripotent Stem Cells book, There is hardly an area of research developing so quickly and raising so many promises as stem cell research. Adult, embryonic and recently available induced pluripotent stem cells not only foster our understanding of differentiation of endo-, ecto- and mesodermal lineages to all organs of the body, but foremost nourish the hope that cells grown in culture can be used for regeneration of diseased organs such as the heart damaged by myocardial infarction. This book focuses on perspectives of stem cells for regenerative therapy of cardiovascular diseases. Based on the EC consortium INELPY, it reviews the field and disseminates major outcomes of this project. Thus it introduces the reader to this fascinating area of research and incorporates very recent findings interesting to the expert, spanning the field from bench to bedside. The compilation of contributions is unique as there is yet no similar comprehensive overview combining stem cell research with preclinical and clinical evaluation as well as engineering of tissue patches for transplantation. As such it will be an invaluable source of information for all researchers in the stem cell and tissue regeneration field including bioengineers as well as for all clinicians interested in regenerative therapies, especially for ischemic cardiomyopathies.



Cardiovascular Regenerative Medicine

Cardiovascular Regenerative Medicine PDF
Author: Vahid Serpooshan
Publisher: Springer
Release Date: 2019-06-29
Book Size: 19.76 MB
Book Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 233
View: 2531

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Cardiovascular Regenerative Medicine

by Vahid Serpooshan, Cardiovascular Regenerative Medicine Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Cardiovascular Regenerative Medicine book, This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.



Cardiac Regeneration

Cardiac Regeneration PDF
Author: Masaki Ieda
Publisher: Springer
Release Date: 2017-10-27
Book Size: 22.23 MB
Book Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 274
View: 1289

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Cardiac Regeneration

by Masaki Ieda, Cardiac Regeneration Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Cardiac Regeneration book, This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.



Arrhythmogenic Consequences Of Stem Cell Therapy For Cardiac Regeneration

Arrhythmogenic Consequences of Stem Cell Therapy for Cardiac Regeneration PDF
Author: Nicoline Willemijn Smit
Publisher:
Release Date: 2018
Book Size: 51.53 MB
Book Format: PDF, Kindle
Category :
Languages : en
Pages : 229
View: 1462

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Arrhythmogenic Consequences Of Stem Cell Therapy For Cardiac Regeneration

by Nicoline Willemijn Smit, Arrhythmogenic Consequences Of Stem Cell Therapy For Cardiac Regeneration Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Arrhythmogenic Consequences Of Stem Cell Therapy For Cardiac Regeneration book,



Gene Therapy And Cell Fusion Enhances Stem Cell Mediated Cardiac Repair

Gene Therapy and Cell Fusion Enhances Stem Cell Mediated Cardiac Repair PDF
Author: Pearl Jennine Quijada
Publisher:
Release Date: 2015
Book Size: 26.85 MB
Book Format: PDF
Category :
Languages : en
Pages : 130
View: 3861

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Gene Therapy And Cell Fusion Enhances Stem Cell Mediated Cardiac Repair

by Pearl Jennine Quijada, Gene Therapy And Cell Fusion Enhances Stem Cell Mediated Cardiac Repair Books available in Docs, PDF, EPUB, Mobi, Textbook, Kindle Format. Download Gene Therapy And Cell Fusion Enhances Stem Cell Mediated Cardiac Repair book, Cardiovascular disease is the leading cause of mortality in the United States. Myocardial infarction (MI) induces massive cellular death and leads to a decline in cardiac function. Cardiomyocytes have limited proliferative capacity sparking interests in molecular and cellular strategies to promote stem cell conversion into new cardiomyocytes. Cardiac progenitor cells (CPCs) are tissue resident stem cells that give rise to cardiomyogenic structures. Although, CPCs introduced into the heart confer improvements in cardiac function after MI, these effects are not sufficient to support complete heart regeneration and prevent heart failure. Studying molecular pathways that contribute to CPC survival and commitment is essential in advancing CPC based therapeutic approaches. Ca2+/Calmodulin-dependent protein kinase II[Delta]B (CaMKII[Delta]B) regulates survival and growth in cardiomyocytes. However, the role of CaMKII[Delta] in CPCs has not been previously explored. CPCs increase nuclear CaMKII after MI and in vitro differentiation suggesting that CaMKII[Delta]B contributes to the regulation of CPC commitment. Overexpression of CaMKII[Delta]B in CPCs reduces proliferation, enhances resistance to death and increases cardiac specific differentiation. CaMKII[Delta]B may serve as a novel modulatory kinase to promote CPC survival and commitment. Despite increasing use of stem cells for regenerative-based cardiac therapy, the optimal stem cell population(s) remains uncertain. In the past decade there has been increasing interest and characterization of stem cell populations reported to directly and/or indirectly contributes to cardiac regeneration through processes of cardiomyogenic commitment and / or release of cardioprotective paracrine factors. Future therapies require development of unprecedented concepts to enhance myocardial healing. Combinatorial cell therapy utilizing CPCs and bone marrow derived mesenchymal stem cells (MSCs) promote enhanced reparative functions in vivo. However, identifying cell specific mechanisms of cardiac repair are difficult using dual cell systems. Here, we performed cell fusion between CPCs and MSCs to obtain hybrids with combined cell characteristics called CardioChimeras. Our ideal cell therapy is to combine the beneficial properties of CPCs to undergo cardiac specific commitment as well as MSCs that foster an improved microenvironment with protective paracrine secretion.